You can even use other options after triggering the Shift-Command-4 keyboard shortcut. Lastly, release the mouse button or trackpad to take the screenshot. This shortcut will convert your mouse into a crosshair and using this crosshair you can select a particular region of the screen to capture. The next best method to take a screenshot on a MacBook is the Shift-Command-4 keyboard shortcut. The screenshot captures using this method will be automatically saved on your desktop.